منابع مشابه
TAp63: The fountain of youth
The mechanisms controlling organismal aging have yet to be clearly defined. In our recent paper [1], we revealed thatTAp63, the p53 family member, is a critical gene in preventing organismal aging by controlling the maintenance of dermal and epidermal precursor and stem cells critical for wound healing and hair growth. In the absence of TAp63, dermal stem cells (skin-derived precursors or SKPs)...
متن کاملIn search of the fountain of youth.
In Greek mythology, Klotho spins the thread of life. In human biology, Klotho protein was so named when researchers discovered that mutations that interrupt its normal function result in a shorter thread of life that is attributable to accelerated aging.1 From its initial discovery, the kidney and its role in phosphate and calcium handling have been at the epicenter of the Klotho story. a, b, a...
متن کاملApical meristems: the plant's fountain of youth.
During postembryonic development, all organs of a plant are ultimately derived from a few pluripotent stem cells found in specialized structures called apical meristems. Here we discuss our current knowledge about the regulation of plant stem cells and their environments with main emphasis on the shoot apical meristem of Arabidopsis thaliana. Recent studies suggest that stem cells are localized...
متن کاملBile acids in the fountain of youth
lucky enough to drink water from the fountain of youth could retard its aging process, as the legend tells. Most likely, water was not the only element in the legendary fountain. What else could be found in there? We may never know! But scientists could come across their own anti-aging ingredients using model organisms and collections of chemical compounds, as the Titorenko's lab reports in thi...
متن کاملNo truth to the fountain of youth.
fforts to combat aging and extend human life date at least as far back as 3500 B.C., and self-proclaimed experts have touted anti-aging elixirs ever since. Indeed, the prospect of immortality has always had universal appeal, spurring Alexander the Great and Ponce de León to search for the legendary Fountain of Youth and feeding alchemists’ desire to manufacture gold (once believed to be the mos...
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ژورنال
عنوان ژورنال: Cell Stem Cell
سال: 2017
ISSN: 1934-5909
DOI: 10.1016/j.stem.2017.04.007